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Accrivir (Acyclovir)

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Accrivir is an antiviral medication that stops a protein (an enzyme called DNA polymerase) in the herpes simplex virus (HSV) and varicella-zoster virus (VZV). Without this enzyme, the virus can't make copies of itself.

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Also known as: Acyclovir


Accrivir Topical (for the skin) is an antiviral medicine that is used to treat skin symptoms caused by the herpes virus.

Accrivir Topical cream is used to treat cold sores on the lips and face.

Accrivir Topical ointment is used to treat genital herpes lesions.

There is no cure for herpes and acyclovir will not prevent you from developing symptoms in the future.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. Topical medicine is for use only on the skin.

Start using acyclovir as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Wash your hands before and after applying this medicine.

Apply only enough cream to cover the cold sore or tingly area.

Apply only enough ointment to cover the genital lesion(s) completely. Wear a glove or a finger cot or use a cotton swab when applying the ointment to avoid spreading the virus to other body parts and to other people.

Accrivir Topical cream is usually applied 5 times daily for 4 days. This medicine ointment is usually applied 6 times daily for 7 days. Follow your doctor's dosing instructions very carefully.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Store at room temperature away from moisture and heat.

Detailed Accrivir Cream dosage information


An overdose of Accrivir Topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Accrivir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Agitation, confusion, dizziness, and drowsiness may be especially likely to occur in elderly patients who are usually more sensitive than younger adults to the central nervous system effects of acyclovir.

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