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Actizide (Glipizide)
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Actizide

Actizide is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself in type 1 diabetes. It is taken by mouth. Effects generally begin within half an hour and can last for up to a day.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glimet, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

Actizide is a medication consists in a class of drugs called sulfonylureas. Actizide is used to treat type 2 diabetes. Actizide may be used along with diet, exercise and insulin therapy. Actizide is also known as Glipizide, Glytop SR. Actizide works by controlling blood sugar levels in your organism. Generic name of Actizide is Glipizide. Brand names of Actizide are Actizide, Actizide XL.

Dosage

Usual Adult Dose of Actizide for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Actizide XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Actizide XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Actizide for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Actizide dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Actizide XL dosage information

Side effects

The most common side effects associated with Actizide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glipizide in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving glipizide.

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Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. In reverse-transcription-polymerase chain reaction (rtPCR), an appropriately sized product was amplified from CG cDNA using primers to the cActR-IIA but not the cActR-IIB. Remarkably, the volumetric energy density and power density of the all solid-state supercapacitor yarn made of one pair of these composite electrodes are 6.1 mWh cm(-3) and 1,400 mW cm(-3), respectively. Evaluation of staff, patient and foetal radiation doses due to endoscopic retrograde cholangiopancreatography (ERCP) procedures in a pregnant patient. This review focuses on the theory of oxygen transport to tissue and presents the state of the art in mathematical modeling of transport phenomena. As shown previously, expression of antisense Goalpha RNA ablated the alpha subunit of the heterotrimeric G protein, Go, resulting in growth in the absence of mitogen. This variant binds CCR5 but exhibits lower chemotactic and antiviral activities than unprocessed RANTES.

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Induction of tolerance requires a threshold level of mixed hematopoietic chimerism. Drug repurposing is currently an important approach for accelerating drug discovery and development for clinical use. These data show an association between No production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE. Results suggest the need for services and treatment strategies that specifically address the risks for violence and promote healthy intimate relationships for youths with CD and ADHD. Overhead traction therapy for misalignment of the hip joint is a safe method reducing damage to the femoral head. Anatomo-surgical characteristics of the renal and iliac vessels in relation to renal transplantation. In most nasal polyps, tissue eosinophilia is a striking finding, the pathologic mechanism of which is not understood. In shock, the presence of hyperlactatemia is prognostic of a failure to survive. Prognosis appears to be excellent because no difference in survival was found between patients and age- and sex-matched controls.

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Arsenic and other metal contamination of groundwaters in the industrial area of Thessaloniki, Northern Greece. The study was aimed at identification of active agents, which can serve as markers of proceeding adaptation changes and to determine, if these changes may be determined in patients undergoing the stage of remission of chronic glomerulonephritis. Pregnancies with maternal medical disease including preeclampsia, premature rupture of membranes, twin-twin transfusion syndrome, and known fetal anomalies were excluded. UDCA has compazine iv medication been shown to exert a protective effect in most studies on patients with UC and concomitant PSC. The transparent WOLEDs can be almost invisible by day and can emit a pleasant diffused light at night, allowing the surface light source to shine in both directions, an exciting new lighting technology that could bring new device concepts. VEGF-mediated activities seem to contribute to the pathogenesis of leiomyoma. Crystallographic study of a beta-lactam inhibitor complex with elastase at 1.84 A resolution. Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions.

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Here a new series-expansion reconstruction procedure, based on isoparametric finite-element concepts, is described. A case study in the use of community-based participatory research in public health nursing. Refractory cholestasis presenting as cholangiolitis in an Rh (E)-incompatible neonate. The aim of this article is to review the literature, and to report two cases of patients whom, following on to odontogenic infections originating from molars in the mandibular arch, developed an odontogenic cervical abscess complicated by pleural effusion, mediastinal empyema and septic shock, with severe risk of a fatal outcome. Both regional health information systems (rHIS) and hospital information systems (HIS) need systematic information management. The Current State of Behavioral Health Quality Measures: Where Are the Gaps?.

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Case of giant extracranial aneurysm of the internal carotid artery. In the second part of the study, NMA was microinjected unilaterally into the head of the caudate nucleus at various postnatal ages (2-80 d). p63alpha expression was differentially regulated with high levels of cytoplasmic expression in clusters of cells in the granular layer of the skin in the transgenic lines 20 weeks after cessation of UV-B exposure, in contrast to uninterrupted staining in the nontransgenic lines. Also, the correct classification of complex karyotypes of solid tumors supports the prognostication of cancer patients. Mechanisms of nerve cell death: apoptosis or necrosis after cerebral ischaemia. The presence of the NO2-synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) (0.1 mM) or of the P2-purinoceptor antagonist suramin did not affect ATP relaxation. Microwave-assisted synthesis of chromenes: biological and chemical importance. Varus deformities of the elbow joint in children after trans- and supracondylar fractures of the humerus and their treatment.

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