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Actizide (Glipizide)

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Actizide is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself in type 1 diabetes. It is taken by mouth. Effects generally begin within half an hour and can last for up to a day.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glimet, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide


Actizide is a medication consists in a class of drugs called sulfonylureas. Actizide is used to treat type 2 diabetes. Actizide may be used along with diet, exercise and insulin therapy. Actizide is also known as Glipizide, Glytop SR. Actizide works by controlling blood sugar levels in your organism. Generic name of Actizide is Glipizide. Brand names of Actizide are Actizide, Actizide XL.


Usual Adult Dose of Actizide for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Actizide XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Actizide XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Actizide for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Actizide dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Actizide XL dosage information

Side effects

The most common side effects associated with Actizide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glipizide in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving glipizide.

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Giant cell tumor of the clavicle: report of a case in a rare location with consideration of surgical method. The objectives of preoperative ventriculostomy are gradual reduction of intracranial pressure and consequent preoperative brain protection. On the other hand, HGF receptor was identified as the product of the c-met proto-oncogene, which encodes a 190-kDa transmembrane protein possessing tyrosine kinase domain. PCR assay for hup B gene is a rapid means of diagnosis of tubercular lymphadenitis. Identification of alpha-thalassemia mutations in subjects from Eastern Sicily (Italy) with abnormal hematological indices and normal Hb A2. Changes in protein content and in vivo incorporation of (35S)methionine elavil medication dose into protein of discrete brain areas of the rat over puberty: sexual differences. Human and non-human primate immunodeficiency viruses: genetic relatedness and phylogeny. In conclusion, continuous epidural administration of droperidol is useful to prevent nausea or vomiting. Drainage and biopsy are mainstay procedures in pediatric interventional radiology. Iron additives for sulfide precipitation significantly improved the process stability and efficiency, whereas aerobic pretreatment of the grains had no effect.

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Findings supported an integrated biological-interpersonal model in explaining the development of depressive symptoms during adolescence. The remarkable ability of the Adiantum interphase nuclei to recover morphologically and physiologically is assumed to be due to processes which also drive the maintenance of the functional nuclear structure during interphase. The use of the polybrene capillary coating has allowed lopressor generic drug name sufficient separation to resolve the large number of digest products formed upon tryptic digestion of the whole protein, so that prior separation of the hemoglobin alpha and beta chains is not required. Differences in presentation of younger and older systemic sclerosis patients in clinical trials. Patients with pseudoachondroplasia have complex, difficult to correct deformities including angular deformity, rotational deformity, and ligament laxity.

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Arsenic and other metal contamination of groundwaters in the industrial area of Thessaloniki, Northern Greece. The study was aimed at identification of active agents, which can serve as markers of proceeding adaptation changes and to determine, if these changes may be determined in patients undergoing the stage of remission of chronic glomerulonephritis. Pregnancies with maternal medical disease including preeclampsia, premature rupture of membranes, twin-twin transfusion syndrome, and known fetal anomalies were excluded. UDCA has compazine iv medication been shown to exert a protective effect in most studies on patients with UC and concomitant PSC. The transparent WOLEDs can be almost invisible by day and can emit a pleasant diffused light at night, allowing the surface light source to shine in both directions, an exciting new lighting technology that could bring new device concepts. VEGF-mediated activities seem to contribute to the pathogenesis of leiomyoma. Crystallographic study of a beta-lactam inhibitor complex with elastase at 1.84 A resolution. Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions.

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As efavirenz is widely used in current antiretroviral therapy, these findings may concern many HIV-infected men wishing to have children. Reactions between activated benzo(a)pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation. The goal of the present study was to address the question of the impact of Xenorhabdus symbionts on the progression and outcome of interspecific competition between individuals belonging to different Steinernema species. Here we show evidence supporting the previous suggestion that Sxl recognizes the sequence context downstream of the uridine-rich sequence. These isolates were also exposed to allopathic drugs, Metronidazole (MTZ), Tinidazole, Trimethoprim-sulfamethoxazole(TMP-SMX), Ketoconazole and Nitazoxanide for comparison purpose. Thoracic diagnostic requirements of an intensive care unit from the anesthesiology viewpoint.

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Here a new series-expansion reconstruction procedure, based on isoparametric finite-element concepts, is described. A case study in the use of community-based participatory research in public health nursing. Refractory cholestasis presenting as cholangiolitis in an Rh (E)-incompatible neonate. The aim of this article is to review the literature, and to report two cases of patients whom, following on to odontogenic infections originating from molars in the mandibular arch, developed an odontogenic cervical abscess complicated by pleural effusion, mediastinal empyema and septic shock, with severe risk of a fatal outcome. Both regional health information systems (rHIS) and hospital information systems (HIS) need systematic information management. The Current State of Behavioral Health Quality Measures: Where Are the Gaps?.

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Case of giant extracranial aneurysm of the internal carotid artery. In the second part of the study, NMA was microinjected unilaterally into the head of the caudate nucleus at various postnatal ages (2-80 d). p63alpha expression was differentially regulated with high levels of cytoplasmic expression in clusters of cells in the granular layer of the skin in the transgenic lines 20 weeks after cessation of UV-B exposure, in contrast to uninterrupted staining in the nontransgenic lines. Also, the correct classification of complex karyotypes of solid tumors supports the prognostication of cancer patients. Mechanisms of nerve cell death: apoptosis or necrosis after cerebral ischaemia. The presence of the NO2-synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) (0.1 mM) or of the P2-purinoceptor antagonist suramin did not affect ATP relaxation. Microwave-assisted synthesis of chromenes: biological and chemical importance. Varus deformities of the elbow joint in children after trans- and supracondylar fractures of the humerus and their treatment.

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