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Actos (Pioglitazone)
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Actos

Actos lowers blood sugar by increasing the body’s sensitivity to insulin and reducing the amount of glucose the liver releases. This allows the body to better remove excess blood sugar. The Food and Drug Administration (FDA) approved Actos in 1999.

Other names for this medication:
Asoride, Bestoglim, Bioglita, Diaglit, Euglim, Euroglip, Gamaryl, Glime, Glimiprime, Glizone, Glucut, Glyciphase, Glycirest, Matce, Metme, Metride, Piodart, Pioglaz, Piokind, Piomeri, Pionorm, Pioriv, Pizorad, Radizone, Tribet, Triexer, Triglimiprex, Triglycomet, Triopil, Tripride, Zogli

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Also known as: Pioglitazone

Description

Actos is an effective drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes mellitus type 2. Actos contains the active ingredient Pioglitazone Hydrochloride. Pioglitazone helps to lower blood glucose levels by increasing the sensitivity of liver, fat, and muscle cells to insulin; enables cells to remove glucose from the blood more effectively, reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas that produce insulin. Actos does not cause the body to make more insulin. Therefore, when used alone, it does not cause low blood glucose (hypoglycemia). Actos is used either alone or in combination with other anti-diabetic medications (such as insulin, metformin, or a sulfonylurea such as glyburide). Actos is not taken to treat type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

-Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day -Patients with congestive heart failure (New York Heart Association [NYHA] Class I or II): Initial dose: 15 mg orally once a day Maintenance dose: 15 mg to 45 mg orally once a day based on glycemic response as determined by HbA1c Maximum dose: 45 mg orally once a day Comments: -This drug exerts its antihyperglycemic effect only in the presence of endogenous insulin and therefore is not expected to be effective in patients with type 1 diabetes mellitus or diabetic ketoacidosis. -Patients concomitantly receiving an insulin secretagogue or insulin may need to reduce the dose of the insulin secretagogue or insulin if hypoglycemia occurs. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings

Detailed Actos dosage information

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Actos overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Actos if you are allergic to Actos ingredients. Do not take Actos if you are in a state of diabetic ketoacidosis. Actos is ineffective and possibly harmful in treatment of type 1 diabetes. Do not take Actos if you have congestive heart failure or heart disease, fluid retention, a history of bladder cancer, heart attack, stroke, liver disease, certain eye problems (macular edema), or polycystic ovary syndrome. Actos is not to be used in people with blood in their urine when the cause of this is unknown. Avoid drinking alcohol. It lowers blood sugar level and may interfere with your diabetes treatment. Be careful with Actos if you are pregnant, planning to become pregnant, or breastfeeding. Do not use Actos in treatment of children under 18 years old. Actos may increase the risk of bone fracture in women (usually in the upper arm, hand, or foot). Actos can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Do not take Actos for longer than recommended. Taking Actos for more than 1 year may increase your risk of developing bladder cancer.

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