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Adefin (Nifedipine)

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Adefin is used to treat hypertension (high blood pressure) and angina (chest pain). Adefin is in a class of drugs called calcium channel blockers. Adefin relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Addos, Adefin, Adipine, Buconif, Cardifen, Cobalat, Conetrin, Cordaflex, Cordilat, Depicor, Depine, Duranifin, Macorel, Marivolon, Myogard, Nifebene, Nifecard, Nifecor, Nifedigel, Nifehexal, Nifelat, Nifical, Nipin, Nyefax, Oxcord, Tensomax, Tensopin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


Adefin should be taken orally with or without food. It is better to take Adefin at the same time every day. Take on an empty stomach. Avoid grapefruit juice during treatment with Adefin. If you want to achieve most effective results do not stop taking Adefin suddenly.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adefin dosage information

Side effects

The most common side effects associated with Adefin are:

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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An investigation of the effects of feeding beta-aminopropionitrile on the growth rate and intramuscular collagen content of broiler chicks. Touchdown PCR: a rapid method to genotype Helicobacter pylori infection. The vaccines currently available are prepared from either live attenuated or killed virus and may be less than reliable. Letter to the editor: Upper arm tourniquet tolerance in hand surgery. This study furthers our knowledge of pathogen survival in wastewater, and suggests that proper management of wastewater before its use in irrigation is essential to reduce pathogen transfer to crops. In conclusion, among the known members of the subtilisin family, only furin and LPC/PC7 fulfill the requirements of a protease responsible for in vivo activation of HIV envelope glycoproteins. In addition, site visits to 17 primary health centres (PHC) assessed diagnostic practice and logistics capacity. In this study, we analyzed the gene expression signatures associated with mammary tumor metastasis and asked for parallels with the human equivalent. In contrast to M2 MVs, which enhanced the insulin-induced glucose uptake measured by 2-NBDG, M1 MVs decreased this effect in treated adipocytes.

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The identity and prevalence of seminal microorganisms before and after processing. A transnasal stereotactic biopsy was performed, revealing an EG. This case report describes the disease presentation in a detained person in police custody in Dumfries, South West Scotland. Two-dimensional echocardiography showed bioprosthetic tricuspid valve malfunction with right atrial thrombus. Mortality in terrorist attacks: a unique modal of temporal death distribution. This study indicates that the synthetic 16S rRNA has a secondary structure in solution similar to a native secondary structure except in two regions, one apparently incorrectly folded during synthesis and the other in which nucleotides which are normally methylated in authentic 16S rRNA may be responsible for a structural difference. Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease that affects one-third of adults in westernized countries. In this manuscript, the effects of gender and sex hormones in sepsis are summarized and potential gender-specific therapeutic strategies in women are evaluated.

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The study sample included 118 children born with very low birthweight and 170 non-very low birthweight controls in Taiwan. The results showed a more pronounced plaque accumulation for silk sutures but there was not a statistical difference. Good prognoses of removable partial dentures were shown in Kennedy Classes I, II, and III arches. Growing evidence suggests that adipocytes may link obesity to cardiovascular diseases (CVD). Moreover, based on protein secondary structural differences, hierarchical cluster analysis was carried out in the 1700-1600 cm(-1) region. We report a clinico-pathological study designed to delineate the aiming criteria required to produce a fistula between the anterior chamber and the canal of Schlemm. This study was conducted to determine whether the cytotoxic agent cisplatin (CDDP), also known as a radiosensitizer, can improve the efficacy of the 131I-labeled monoclonal antibody (MAb) 323/A3 in the treatment of experimental human ovarian cancer. Increasing use of heroine and cocaine in Switzerland since 1990: use of a generalized Poisson distribution in the collected data. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from homologous tissues and bacteria. An intriguing maintenance strategy could be the combination of the angiogenic agent bevacizumab (Bev) with a convenient and well tolerated chemotherapy agent such as oral etoposide.

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Hyperestrogenic nature of the hormonal balance was diagnosed in patients with the newly developed systemic lupus erythematosus. We examined the cost-effectiveness of dextranomer/hyaluronic acid copolymer injection in patients who would otherwise undergo ureteral reimplantation. The present study suggests a direct relationship between the malleability of negative attention bias and the ERN. The aim of this meta-analysis was to assess whether this type of radiotherapy could improve survival. A comprehensive genetic analysis of 310 MB samples was performed by screening for TP53 mutations and further relating the TP53 mutation status to p53 immunostaining, cytogenetic aberrations, and clinical variables. Another derivative was used to recruit a cytosolic protein to the plasma membrane, mimicking a process involved in many signaling pathways. The LF material-laden basal cells and intraepithelial macrophages appeared to leave the epithelium, accompanied by recruitment of fresh basal cells and intraepithelial macrophages.

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Beyond this interaction, little is known about the mechanisms underlying Gliotactin localization and function at the TCJ. General practice instruction in the hospital--results of a nursing education study: structures are often still heterogeneous. We examined whether the subglacial bacterial community shares common members with the pro- and supraglacial communities, and by inference, whether it could be derived from communities in either of these environments (e.g., by ice overriding proglacial sediments or by in-wash of surface meltwaters). Advances in medical imaging have made it possible to study this shape variation in vivo. Conceptus and uterine tissues were collected from gilts throughout normal pregnancy and processed for immunohistochemical characterization. Haemoglobin response to anabolic steroid in iron-deficiency anaemia.

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Risk factors associated with soft coronary artery plaques in Japanese, as determined by 16 slice multidetector-row computed tomography. Role of abdominal echocardiography in the preoperative diagnosis. Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal mongolian gerbil (Meriones unguiculatus). There was scintigraphic evidence of bone metastasis in most of our patients with stage four breast cancer and in some with locally advanced disease. These results suggest that vanadate stimulates in part the PDE activity through the activation of the particulate MBPK, probably MAPKs, by PTK sensitive to vanadate. To examine the feasibility of using a peripheral dual energy X-ray absorptiometry (DXA) scanning service in a nurse-led clinic and whether or not it would influence treatment and clinician satisfaction with the service. Although the treatment within the emergency room is temporizing in nature, to better understand these problems and their appropriate management, these areas will be discussed as to their etiology, treatment, and prognosis.

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Hemodynamics of the isolated perfused rat kidney in the absence and presence of kallikrein substrate. The effect of antidiuretic hormone on the extravascular protein in the renal medulla. For those patients who underwent a non urgent operation and especially laparoscopic surgery higher pain score was recorded in the group B from the 3rd PO day onwards. Quantitative determination of the luminescence of norepinephrine in paraganglia. We used logistic regression to analyze the odds of receiving a BMT stratified by disease type (leukemia or lymphoma). The elevated pressure in patients suffering from achalasia is significantly reduced by glucagon. Dynamic determination of the position of equilibrium for a joint. Intracellular PV-1 is localized in perinuclear aggregates that can extend as a fibrous network through the cytosol and often surround the nuclear compartment. Coronary blood flow and myocardial reactive hyperemia in the ischemic dog heart.

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The examinations were evaluated blind on a five point scale and statistical analysed by a regret function. Renewed professional education, cutting through fiscal intricacies, and integration of care for tuberculous persons into general medical and hospital care will maintain high standards of tuberculosis control. Upon clinical recognition of an orbital venous anomaly, brain imaging and appropriate clinical assessment should be considered in light of the possibility of coexistence of potentially life-threatening lesions. Coprinellus congregatus generates several chitinases during its entire life cycle: at the growing hyphal stage and at the mushroom autolysis stage. Plasma endothelin in psoriasis: possible relations to therapy and toxicity. Injuries to the radial nerve or posterior interosseous nerve can lead to significant functional limitation. Establishing the etiology of gastrointestinal complaints is often difficult because any one or a combination of these factors might be contributory in the same patient. Climbers are venturing into the mountains and attempting routes with ever-increasing difficulty, and it is important to understand the injury and illness concerns of alpine climbers better. The synthesis of new 1beta-methylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described.

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Proceedings: Free isoelectric focusing of bovine lens gamma-crystallins in a coil of polyethylene tubing. Results of 273 stereotaxic operations enalapril y alcohol in 163 ICP patients are analyzed. Use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. Transfection assays showed that HNF-3 cooperates with the glucocorticoid receptor in stimulating transcription. Furthermore, we show that CED-9 achieves its anti-apoptotic effect by associating with CED-4 and blocking the ability of CED-4 to process CED-3. The use of anticoagulant agents in VTE prophylaxis and treatment in the elderly is complicated by an increase with age in the presence of multiple risk factors and co-morbidities that may increase the risk of both VTE and bleeding.

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Recently, the receptor for IgG on human platelets has been identified and characterised. Bullous fixed drug eruption induced by paracetamol: report of a case. Feeding, paradoxical sleep, analgesia, submissive behavior, and avoidance behavior, are generally increased in diabetic compared with nondiabetic rodents. 2) We believe that our longer hospital stay is due to certain lack of confidence with the technique and, in the future, the trend should be bent on encouraging a shorter time to first feeding and an earlier discharge. In 32 patients the pathogen was eradicated, in one patient it persisted and in seven it reappeared. Spontaneous correction of a traumatic kyphosis after posterior spinal fusion in an infant. Mutation of Tyr85 to Phe, His, Cys, Ser and Ala decreased the RNA affinity by 1-3 kcal/mol under standard binding conditions. The aim of our study was to explore diagnostic and prognostic markers and, prospectively, establish diagnostic and therapeutic algorithm for patients with PMR and GCA. From the experimental point of view, this requires the combined use of a suitable multiple-frequency EPR source and a multiple-tuned EPR resonator.

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People with intellectual disability (ID) leaving institutions pass through a transition stage that makes them vulnerable to inadequate health care. Drupes mechanically harvested and inoculated with Lactobacillus pentosus OM13 were characterized by the lowest concentrations of potential spoilage microorganisms. To analyze the features of the filtering blebs following implantation of the Ex-PRESS glaucoma device (model P-50) with the aid of the Visante anterior segment optical coherence tomography (AS-OCT). The most probable trajectory over which photons can be found can be obtained from this Lagrangian. Enhancing the osteoinductive properties of hydroxyapatite by the addition of human mesenchymal stem cells, and recombinant human osteogenic protein-1 (BMP-7) in vitro. The current model for monolignol and ferulate biosynthesis appears to be an over-simplification, at least in alfalfa, and additional enzymes may be needed for the 3-O-methylation reactions of S lignin and ferulate biosynthesis. Recent advances indicate that the widespread use of biomarkers may herald the next major advance in the diagnosis and management of CRC. The notch signaling system is present in the postnatal pituitary: marked expression and regulatory activity in the newly discovered side population.

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Studies of the population trends for abdominal aortic aneurysms (AAAs) in the period 1970 to 2000 all indicated that the incidence of AAAs was increasing. Further evaluation of the patient showed major manifestations of Williams syndrome in form of supravalvar aortic stenosis, branched pulmonary artery stenosis along with cardiomyopathy. The excited state dynamics of the two molecules in hydrogels was investigated by means of femtosecond transient absorption spectroscopy, revealing the distribution of the dyes between the hydrophobic domains and the water pools making up the microscopic structure of the surfactant hydrogels. Serine supplementation was able partly to restore the ABA sensitivity of gapcp1gapcp2, indicating that amino acid homeostasis and/or serine metabolism may also be important determinants in the connections of ABA with primary metabolism. The design of disulfide bridges is discussed in terms of protein flexibility.

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Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. This study sought to investigate whether cytokine expression in leukocytes may be induced by plasma from the reperfused heart of patients with an acute myocardial infarction (MI). Extrusion of benzoic acid in Saccharomyces cerevisiae by an energy-dependent mechanism. LE cell sensitization has effects, resembling hyperalgesia and allodynia, that compensate for loss of sensory function during injury and help protect against subsequent threats. The expression of platelet-derived growth factor A (PDGF-A), and its spatial and temporal relationship to interstitial collagens in kidneys with congenital multicystic dysplasia using in situ hybridization, have been examined. Thus, using a least-squares line, it was possible to characterize a cartridge with unknown apparent activity. Pectus carinatum is a cosmetic problem, but its presence can be psychologically devastating to the patient. And we propose and demonstrate timing offset effect reduction in asynchronous multiple access by using CP extension and filter bank based multicarrier (FBMC) system in intensity modulation/direct detection (IM/DD) based OFDMA-PON uplink transmission. The authors studied the effect of arimidex drug test exogenous glutamine (GLN), with and without growth hormone (GH), pretreatment, on gastrointestinal, hepatic, femoral, and renal GLN fluxes. Fluorescent derivatives of the polyethers were prepared by reaction of their sodium salts with 1-bromoacetylpyrene and Kryptofix 222 in acetonitrile.

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Three pairs of twins joined from diaphragm to pelvis and facing each other in an embracing posture were separated in the last 10 years at a single institution. Twenty patients were randomly assigned to receive only ZDV (1st group) or ZDV together with HIV-1-specific TF (2nd group). We present here a new continuum theory of collective motion coupling the velocity and density fields of Toner and Tu to the inertial spin field recently introduced to describe information propagation in natural flocks of birds. Olfactomedin-related proteins 4 (OLFM4) expression is involved in early gastric carcinogenesis and of prognostic significance in advanced gastric cancer. Methodological principles of organization of such a register at a territorial level are described, which will permit including the information collection for the register into the already existing in Russia system of official registration of disabled children and coordinate it with the international recommendations on relevant problems. Evaluation of two methods of following women who have been treated because of exposure to gonorrhea. To determine which ecdysteroids may be biologically active in the larval epidermis of the tobacco hornworm, Manduca sexta, we studied the action of several known ecdysteroids and metabolites on the expression of the genes encoding the ecdysone receptor (EcR), Manduca hormone receptor 3 ventolin hfa albuterol dose (MHR3), dopa decarboxylase (DDC), and a larval cuticle protein (LCP-14). Despite NICE referral recommendations, a significant proportion of patients are still not managed within recommended care pathways to CRC diagnosis. The existence of these corticopontine pathways from prefrontal areas concerned with multiple domains of higher-order processing is consistent with the hypothesis that the cerebellum is an essential node in the distributed corticosubcortical neural circuits subserving cognitive operations. Relations that allow the calculation of the noncollinear phase-matching angle for any case of SHG are established.

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Neuropathological studies included light and electron microscopy of cerebral and nerve biopsies, and a complete postmortem examination. To investigate the usefulness of measuring the intra-operative electrically evoked compound action potential (ECAP) and electrically evoked auditory brainstem response (EABR) in patients with and without congenital inner ear anomalies during cochlear implantation. After up to 6 months of pressure elevation, optic nerve head sections from the rats were evaluated by light microscopic immunohistochemistry using antibodies to collagens I, III, IV and VI, laminin, elastin and chondroitin and dermatan sulfate proteoglycans. Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis. For example, eicosapentaenoic acid and docosahexaenoic acid may inhibit the synthesis of several prostaglandins and leukotrienes, as well as reduce the cellular production of cytokines or growth factors such as interleukin-1 or platelet-derived growth factor.

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In the first case the presumptive diagnosis of lung carcinoma was made from the discovery of atypical cells in pleural fluid. In response, Petrov and Williams dismissed our arguments claiming we did not understand their algorithmic model of ribosomal apical growth. Genital infection with human papillomavirus (HPV): viral screening and typing bisoprolol fumarate 20 mg , importance of in situ hybridization. Proceedings: The effects of local continuous stimulation with the contact agent DNCB. The result can be interpreted as a hint that signals for the control of erythropoietin production may be mediated by beta 2-adrenergic receptors rather than by beta 1-adrenergic receptors. Value of laparoscopic ultrasonography in staging of proximal bile duct tumors.

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