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Alpose (Alprazolam)

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Alpose is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpose, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpose is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aleez, Alpraday, Alprotame, Alzokam, Alzolite, Alzopam, Alzorix, Anxigon, Axnil, Cardilax, Censir, Emcalm, Endep, Erazol, Esteem, Exiten, Fluprax, Himzolam, Imprax, Jolistar, Mebaspa, Meloprax, Normatine, Ozolam, Paxor, Romipraz, Sinzolam, Somaspas, Somnia, Tancalm, Tensyl, Zamitol, Zolin, Zoloid, Zolyde

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Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpose XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpose XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpose XR dosage information

Side effects

The most common side effects associated with Alpose are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: kava, sodium oxybate.Other medications can affect the removal of Alpose from your body, which may affect how Alpose works. Examples include azole antifungals (such as itraconazole, ketoconazole), cimetidine, certain anti-depressants (such as fluoxetine, fluvoxamine, nefazodone), drugs to treat HIV (delavirdine, protease inhibitors such as indinavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (such as diphenhydramine), medicine for sleep or anxiety (such as diazepam, zolpidem), muscle relaxants, narcotic pain relievers (such as codeine), psychiatric medicines (such as chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients which cause drowsiness. Ask your pharmacist about the safe use of those products.Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

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Mitochondria are known to be one of major organelles within a cell and to play a crucial role in many cellular functions. We have successfully used both techniques to generate chromosomal mutations in E. In this article we present an optical biosensor for label-free detection of trace levels of protease activity. Progressive resistance exercise (PRE) is a method of increasing the ability of muscles to generate force. Relaxing on a bed of nails: an exploratory study of the effects on the autonomic, cardiovascular, and respiratory systems, and saliva cortisol. Ideal guidewire placement was defined as the center of the femoral head, 5 mm from the apical bone edge on anteroposterior and lateral views. Detection of anti-tumour cell mediated immunity and serum blocking factors in cancer patients by the leucocyte adherence inhibition test. Tarenflurbil, a selective Abeta(42)-lowering agent, demonstrated encouraging results on cognitive and functional outcomes among mildly affected patients in an earlier phase 2 trial. Reports of studies that examined effects of any therapy derived from a psychological approach that satisfied prespecified criteria were reviewed. This multinomial model serves as a core model to perform a Bayesian evidence synthesis.

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The expression of p21/WAF1 and MDM2 can be considered as 2 useful indicators for predicting the prognosis of HCC. Descriptive analysis of the verbal behavior of a therapist: a known-group validity analysis of the putative behavioral functions involved in clinical interaction. Blacks had more medication-related problems than whites, including higher rates of nonadherence. HBV DNA quantification is currently used for selecting candidates for therapy, monitoring response to therapy and detecting the emergence of drug resistance. In the tamponade group, bleeding persisted beyond 17 minutes in 2 and a large clot formed at 12 minutes in 1 case that precluded further assessment. The quality of care for colorectal cancer provided by a hospital system is somewhat consistent across the immediate postoperative and long-term follow-up periods. Strikingly different structure-activity trends were observed, namely the association of E isomers with potent NQO1 induction activity and Z isomers with growth inhibitory properties.

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Epidemiologic and clinical characteristics of 59 persons suspecting of being infected by the HIV virus despite having repeated negative laboratory findings. Professional societies have been reluctant to enter actively into the public processes by which decisions are made on economic, social, and political issues. We demonstrate in a large population that common maternal polymorphisms of genes related to immune tolerance and inflammation are associated with blood pressure regulation, urinary protein excretion and oedema during pregnancy. We studied whether exercise affects expression of angiotensinogen and angiotensin-converting enzyme (ACE) and tissue angiotensin II level in the kidney. The day care laparoscopic cholecystectomy (DCLC) is found to be safe and effective in developed countries. The trials were registered, numbers NCT00425984 and NCT00124878. Optically pure (S)- and (R)-vinylpiperidine 2 and (S)- and (R)-(hydroxyethyl)piperidine 3, which were key intermediates for the synthesis of aloperine, were synthesized from yeast-reductive products. Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis.

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Sixty rabbits from the 23rd generation (group S) of a line selected for growth rate were compared to sixty rabbits from the 7th generation of the same line (group C) to study possible relevant changes in carcass composition and meat quality due to the selection and the consequent decrease in degree of maturity at slaughter weight (2000g). Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. As expected, TmxB folds into a (beta/alpha)8-barrel structure, which is common among the glycoside hydrolase family 10. Three maternal deaths occurred, yielding a case fatality rate of 5.9 percent. Spontaneous formation of the unlocked state of the ribosome is a multistep process. The numerical simulation in this paper extended the structural simulation based on the quantitative bone remodeling theory to bone morphological abnormity in orthopaedics, which can help to better understand the relationship between bone morphological abnormity and the mechanical environment. Additionally, steady-state fluorescence spectra suggest conformational differences between CAR(TCPOBOP):RXR and CAR(meclizine):RXR.

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With strictly selected controls natural killer cell activity was evaluated in 10 untreated patients with systemic lupus erythematosus. Effects of salt stress on their expression were studied with quantitative PCR and their potential use in the genetic engineering of oilseed rape was discussed. It is likely that the oxidative cleavage of disulfide bonds between cuticle-constituting proteins, including S100A3, results in the fragile property of cuticles. A HupS-GFP fusion protein demonstrates a heterocyst-specific localization of the uptake hydrogenase in Nostoc punctiforme. Retrospective, population based, case-control study by questionnaire. We propose that conditions with altered capillary morphology, such as amyloid, diabetic or hypertensive microangiopathy, and ischemia-reperfusion, may disturb CTTH and thereby flow-metabolism coupling and cerebral oxygen metabolism.

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In this work, two drugs used to treat DM, pioglitazone and rosiglitazone, were studied using theoretical methods, and their molecular properties were related to the biological activity of these drugs. Soil respiration and root biomass responses to burning in calabrian pine (Pinus brutia) stands in Edirne, Turkey. To date 43 different variations in EPM2A and 23 in NHLRC1 are known, including missense, nonsense, frameshift, and deletions. Dyskeratosis congenita (DC) is a rare genetic syndrome that gives rise to a variety of disorders in affected individuals. Development of a convenient tool for the extraction of cell-bound biosurfactants and bacteriocins from the fermentation broth.

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The predominant species were Staphylococcus saprophyticus, Staphylococcus xylosus and Staphylococcus simulans. Two types of vesicles from the erythrocyte-ghost membrane differing in surface charge. These events contribute to the switch of C2C12 cells from a proliferating to a differentiating phenotype. The patient began a low-methionine and low-cysteine diet and was treated with thiamine and dextromethorphan. Differences in cell morphology and the presence of unusual pigments in birds are suggested to be the result of evolutionary changes that followed the divergence of birds from reptiles. No differences in aesthetic outcome or patient satisfaction between anatomically shaped and round expandable implants in bilateral breast reconstructions: a randomized study. Use of an artificial neural network to predict head injury outcome. Patients with an ICD-9-CM code for AF (427.31) were randomly selected. Preclinical studies using genetically altered mice and biological or small molecule inhibitors have elucidated a role for PAI-1 in the pathogenesis of thrombosis, vascular remodeling, renal injury, and initiation of diabetes.

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Abdominal part artery of axillary artery: proposed term for the artery supplying the abdominal part of the musculus pectoralis major. Inhibition of translation initiation factors might be the potential therapeutic targets for HCV patients with hepatic iron overload. Finally, work in the presence of a BH4 analog indicated that proton transfer to the activated oxygen complex is a second essential function of BH4. Our results suggest that new construction and staffing of PCI laboratories may not be warranted if an emergency medical services strategy is both available and feasible. The adaptation algorithms, both intertalkspurt and intratalkspurt based, rely on short term estimations of the characteristics of network delay that would be experienced by up-coming voice packets. We measured extracoronary atherosclerotic plaque burden and its association with cardiovascular risk factors and with coronary atherosclerosis in male marathon runners. Implications for cancer survivorship interventions are discussed. We conclude that our memory management approach is simple, efficient, and effective for genome-wide association studies. Letter: Situation of the diabetic child and adolescent in Western Germany. A sociobiological approach to the study of coronary heart disease.

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Although the functions of phytochromes in gravitropism and chloroplast development are normally considered distinct, our results indicate that these two functions are closely related. The Harris and Beath footprint: interpretation and clinical value. The prevalence of abnormal cervical cytology in women with infertility. Quantitative evaluation of nuclear cataract using image analysis. In additional studies, groups of hamsters were immunized by intravenous injections of glucan with Formalin-killed promastigote-stage L. Adult patients who were admitted to the ICU and required both a central venous line and an arterial line were enrolled. Analysis of CIITA/RFX5 double-deficient animals revealed that this inducible MHCII expression is genetically independent of the known promoter complex and thus constitutes an alternative MHCII expression pathway. The fluoride-induced osteosclerosis seems to be reversible, but the long-term significance of fluoride accumulation in the body is not known. Repellency of naturally occurring volatile alcohols to fungus gnat Bradysia sp.

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NPCs in the anterior subventricular zone (SVZa) generate neuronal precursors and migrate along a highly localized pathway--the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into interneurons. Synthesis of functionalized vinylgermanes through a new ruthenium-catalyzed coupling reaction. The process of the revision of staging system for lung cancer(UICC-7). Digital subtraction angiography (DSA) showed an arteriovenous fistula (AVF) of the right extracranial vertebral artery (VA) with a giant venous pouch and an intracranial berry aneurysm of the right middle cerebral artery (MCA). The above pattern of results has been labelled the attentional blink (AB). The 1957 H2N2 subtype (Asian flu) was one of the three great influenza pandemics of the last century and caused 1 million deaths globally from 1957 to 1968. Many participants felt that sleep problems reduced their productivity, concentration, social interactions, and overall quality of life.

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In this report, we report the case of a 54-year-old man with primary cardiac lymphoma who presented with progressive abdominal distension and oedema of the lower extremities. Comparative effects of six probiotic strains on immune function in vitro. Other HDACI such as M344 and valproate showed similar effects as investigated in one OS cell line. Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease. However, these models have their own model assumptions and pre-defined underlying relationship between dependent and independent variables. Ultrasound guidance decreases complications of central venous catheter (CVC) placement, but risks of arterial puncture and inadvertent arterial catheter placement exist.

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Variables associated with the assessment of systemic tumor necrosis factor alpha levels during hemodialysis. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. pBcl-2 and pBax expression were immuno-stained with streptavidin-biotin (SAB) method. It is not therefore surprising that research in this field is growing exponentially in recent years, and sarcopenia has been placed in recent years in the forefront of research in geriatric medicine and gerontology. In addition, 19-Atriol was an even more potent inhibitor of PK 11195-stimulated steroidogenesis, with activity in the high nanomolar range. Here, we provide a brief ultram brand name update on recent developments in this emerging area and highlight the potential role played by airway smooth muscle. He underwent an uneventful transurethral resection of the prostate. Subgrouping of patients according to CM diagnosis has the potential to provide opportunities for better treatment outcomes by targeting Western or CM treatment to specific groups of patients. Treatment of abstinence is also supportive, while delirium may be treated as delirium tremens. Apprehensions of coping incompetence and responses to fear in old age.

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Associations of stress and depressive symptoms with cancer in older Mexican Americans. The aim of this study was to evaluate the effect of tibolone on vascular resistance of the central retinal and ophthalmic artery in postmenopausal women and to compare this effect with that of placebo using transorbital ultrasound with Doppler velocimetry. AMI was defined on CA by the presence of acute occlusion or critical stenosis with intracoronary fresh thrombus easily crossed by an angioplasty wire. BR increases the RNA levels of ILI1 and PRE1 but represses IBH1 through the transcription factor BZR1. As for infectious hepatitis, it is remarkable that despite the recommendations of the National Board of Health to vaccinate immigrant children against hepatitis A before a visit to their native country, this seems to be far from the actual practice. Specifically the cytoplasmic fraction shows a gradual increase of the Cu,Zn-superoxide dilantin loading dose iv dismutase activity with age, whereas the glutathione peroxidase activity is constant from birth.

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Although the top layer was frozen for some time, the storage capacity of the swale was sufficient to store the precipitation until the conditions improved. In this study, we performed phenotypic analysis of novel A(H1N1) virus to evaluate its pandemic potential and its suitability for use in developing a live attenuated influenza vaccine. The presence and location of aquaporins -1, -2 and -3 in the fetal specimens were then compared to the adult specimens. Intrathecal Catheterization by Epidural Catheter: Management of Accidental Dural Puncture and Prophylaxis of PDPH. Columnar cell lesions (CCLs) of the breast have been increasingly recognised in biopsies taken to investigate mammographic screen detected microcalcification. Prospective evaluation of interstitial laser coagulation of the prostate: importance of surgical technique and patient selection. The long-bone radiographs of a group of nondivers consisting of 177 U.S. Using male and female mice, we tested whether the Engrailed (En) homeobox genes are a common genetic substrate regulating all three systems, since they are expressed in spatially restricted domains within the cerebellum and are critical for patterning PC gene expression and foliation. Thereafter, growth failure became evident, leading to the diagnosis of pituitary hormone deficiency.

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Giant cell arteritis is a granulomatous vasculitis of the aorta and its branches that causes blindness, stroke, and aortic aneurysm. Application of denaturing gradient gel electrophoresis (DGGE) to the analysis of endodontic infections. These results suggest that schizophrenics have impaired central inhibitory mechanisms over a fairly broad range of background noise to prepulse ratios. Comparison of surface plasmon resonance spectroscopy and quartz crystal microbalance techniques for studying DNA assembly and hybridization. Additionally, a growing body of evidence strongly suggests that high dietary salt loading exerts detrimental exelon drug class cardiac effects independently of its hemodynamic load. (4) Although Representatives from the Pacific Coast states are the strongest proponents of regulation, they are opposed to spending (5) Opposition to health care spending is particularly strong among Representatives from suburban districts.

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