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Alrest (Clonazepam)
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Alrest

Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. Alrest helps to stop convulsions and epileptic seizures. It is widely used among people with severe panic attacks and anxiety caused by depression treatment.

Other names for this medication:
Adnil, Almac, Clonapik, Clonasig, Clonatrac, Clonax, Cloneepam, Clonoasig, Clonopam, Clonotril, Clonzy, Clotweet, Cloze, Clozep, Clozipam, Cozil, Deptune, Dipwell, Easyfeel, Eminaz, Epizam, Escitrac, Estalonix, Ezinite, Jasoclam, Jbcloz, Lonipax, Lozep, Meloprax, Melzap, Nazee, Nozim, Prasilex, Prasilife, Repam, Rivotril, Sezolep, Somnolex, Somnotril, Ubitpam, Xenotril, Zeficar, Zepam, Zepamax, Zicam, Zolpidox, Zozep

Similar Products:
Anafranil, Actos, Rebetol, Imdur, Abilify, Bystolic, Priligy, Astelin, Desyrel, Combantrin, Dipax, Xitzen, Arcium, Buson, Osimet, Tupent,

Also known as: Clonazepam

Description

Alrest, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Alrest has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Alrest. As a result, Alrest is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Alrest is mainly prescribed for the acute management of epilepsies. Alrest has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Alrest; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.

Dosage

This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Alrest Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.

Storage

Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Alrest if you have:

narrow-angle glaucoma; severe liver disease; or a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Alrest is safe for you, tell your doctor if you have ever had:

kidney or liver disease; breathing problems; depression, mood problems, or suicidal thoughts or behavior; or porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Some people have thoughts about suicide when taking seizure medication. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

If you use clonazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonazepam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Alrest is not approved to treat panic disorder in anyone younger than 18 years old.

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Outpatient management of superficial venous insufficiency at a naval medical facility. Our data indicate that an association between type 2 diabetes related SNPs and CAD exists. New means of surgical visualization are allowing more surgeries to be performed less invasively. Tooth transpositions--a review of the literature and treatment considerations. The OmpA protein was found to be translocated across the plasma membrane of both microorganisms. Washed platelets were aggregated at 20 or 37 degrees C with ADP (0-20 microM), arachidonic acid (0-200 microM), or the thromboxane mimetic U46619 (0-9 nM). The program had approximately 344,000 participants in 1975 and has grown to provide services to nearly 6 million participants. Radioprotective effect of S-(N-(3-aminopropyl)-2-aminoethyl)-thiophosphoric acid. These patients have unique characteristics and causes of injury. Anxiety disorders and symptoms are a common presenting problem in the elderly.

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The correlation coefficients (r) of the experimental and predicted Caco-2 apparent permeability for the training set and the test set were 0.88 and 0.85, respectively. In order to verify this notion, the number of experimental trials was quadrupled for 24 subjects of mixed sex in a replication of the initial paradigm. The occurrence of three different synergistically active bacterial species from one clinical specimen might be of clinical significance. Achievements and constraints to date and plans for the future are described. Many conditions of atypical development can lead to autism, including fragile X syndrome (FXS), which is presently the most common known single-gene cause of autism. Treating leaks following LSG based on the timing of presentation, presence of stricture, and malnutrition is safe and effective. Reassessment of a non-hemophilic reagent for factor VIII (AHF) determination. Birth preparedness and complication readiness (BP/CR) strategies are aimed at reducing delays in seeking, reaching, and receiving care. hislopii latex on the concentrations of total proteins and nitrogen products in Biomphalaria glabrata infected with Schistosoma mansoni.

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Poor growth and malnutrition are frequently reported in children with cerebral palsy in developed countries, but there is limited information from developing countries. Neutralization of TNF-alpha or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. A multidimensional parameter space, where each dimension is associated with one of the partition parameters, is introduced in order to describe the interaction between partitions and pulse sequence events (e.g., rf pulses and gradients). Detection of Saccharomyces cerevisiae chromosome size markers directly on Southern blots of pulsed-field gels with a single DNA hybridization probe. Little is known about alternative pain self-treatments used by HF patients with chronic pain.

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This interpretive phenomenological study identified three themes of schizophrenia and violence: Being Stigmatized, Foreclosing a Future of Possibilities, and Finding Meaning in Symptoms. Bacteriuria in children attending a primary health care clinic: a prospective study of catheter stream urine samples. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Anatomic bases of a vascularized allogenic knee joint transplantation: arterial blood supply of the human knee joint. In Drosophila, the Gal4/UAS method has been used to analyze in vivo such functional substitutions. To better understand the epidemiology of pertussis and optimize disease control, it is important to improve surveillance worldwide, irrespective of pertussis vaccine types and schedules used in each country. A focus for regulation is the initiation of the first replication forks, marking the transition from G1 to S phase. Calcium release from the mineral matrix of the mandibular bone due to hydrogen peroxide exposure. Finally, while referring to the literature, they discuss the way these factors might operate in the course of the disease.

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This study is an investigation of the impact of Type 1 diabetes on bone mineral density (BMD) with regard to bone composition. Population screening might provide a mechanism to enable early detection of dementia. The procedure smooths parameters and computes p-values locally to account for the complex structure of the genome and to more precisely estimate the differential expression of chromosomal regions. Characteristics of the repeat prosthesis of patients who have worn dentures for a long time. TLQoS exploits modular architecture wherein different modules perform integrated operations in providing multiple QoS service with lower temperature rise. It is concluded that lipids structurally and energetically maintain the neurosecretory material synthesis. Comparative clinical trial of tetracycline-oleandomycin combination and tetracycline in acute pharyngo-tonsillar infections. The effect of fluid from the cauda epididymidis, serum components and caffeine upon the survival of diluted epididymal hamster spermatozoa. However, each receptor splice variant differed in their ligand-stimulated efficacy for total inositol phosphate stimulation. The cells were able to incorporate 16 of 17 (14)C-labeled amino acids into cell protein, the exception being proline.

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Only three mutations, two present homozygously, are reported in the GTP cyclohydrolase I gene to cause the rare autosomal recessively inherited form of hyperphenylalaninemia. Microsatellite markers for powdery mildew resistance in pea (Pisum sativum L.). Both endogenous and exogenous GDF-9 was demonstrated to up-regulate focal adhesion associated proteins FAK and paxillin which contribute to promoted cell adhesion and motility. We report the development of a retroviral vector system in which two dominant oncogenes are expressed inducibly in human cells using the lac repressor/lac operator regulatable promoter system. Options for modulating intra-specific competition in colonial pinnipeds: the case of harbour seals (Phoca vitulina) in the Wadden Sea. Our findings demonstrate, for the first time, a role of CXCL12-CXCR4 signalling axis in conferring drug resistance to pancreatic cancer cells and suggest that it could serve as a novel therapeutic target for pancreatic cancer therapy, alone and in combination with the cytotoxic drug. A large-plot field experiment was carried out in Herefordshire, UK, during 2010-2011.

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Serum cholesterol level in normal people: association of serum cholesterol level with age and relative body weight. The second error arises from the spontaneous variability of blood pressure, such that single clinic readings may vary by as much as 20 mmHg. A rare case of adenocarcinoma arising in adenomyomatous hamartoma of the pyloric wall is presented and the literature reviewed. Imatinib mesylate is recommended as adjuvant therapy for GIST after surgical resection. The first disease-specific quality-of-life questionnaire in patients with drug hypersensitivity, Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q), was developed and validated recently.

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Calcium and calmodulin are involved in blue light induction of the gsa gene for an early chlorophyll biosynthetic step in Chlamydomonas. Previous research has suggested a dose-response relationship between exposure to the 9/11 terrorist attacks and posttraumatic stress disorder (PTSD) and depression. Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen. Parameters affecting the use of the lac repressor system in eukaryotic cells and transgenic animals. Expanding endoprosthesis for pediatric musculoskeletal malignancy: current concepts and results. The electron-microscopic structure of the vasa recta of the kidney medulla of the rat under various fixation conditions. He received surgical treatment with frontal sinus curettage and obliteration with tibial bone graft and platelet-rich plasma (PRP). Purification and amino acid sequencing of naturally occurring N-formyl-methionyl oligopeptides from Escherichia coli. Different mechanisms and contributory factors for the development of AR are discussed.

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Experimental autoimmune uveitis (EAU) is a T-cell-mediated autoimmune disease directed against retinal proteins and has been studied in several mammalian species including subhuman primates as a model for human what is the generic brand of lipitor posterior uveitis. To determine whether use of cardioselective beta-blockers, nonselective beta-blockers, ACE inhibitors, thiazide diuretics, calcium channel blockers, or other antihypertensive drugs alters the risk of developing serious hypoglycemia among older persons prescribed insulin or sulfonylureas. The consensus oligonucleotides should be valuable probes in the diagnosis and isolation of nucleic acids encoding proteins of the troponin C superfamily. A total of 2000 fecal specimens was investigated, 1000 from patients suffering from diarrhea and 1000 from healthy persons which served as controls. It has been established that the prognosis of the working ability largely depends on clinical (biological) and social factors (working education, familial status, living conditions, etc.). However, the molecular mechanisms regulating these intracellular transport events had not been studied until recently because of the lack of appropriate molecular assays and techniques. Radiofrequency catheter ablation for supraventricular tachycardias: experience at Peshawar. The expression of high-mobility group box protein-1 in temporomandibular joint osteoarthritis with disc perforation. Extending staining time to more than 8 h with chromosome suspensions isolated from cell lines subjected to sufficient metaphase arrest times gave the best result with the lowest percentage of debris generated, tighter chromosome peaks with overall lower coefficients of variation, and a 1- to 5-fold increase in the yield of isolated chromosomes.

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