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Alrest (Clonazepam)

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Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. Alrest helps to stop convulsions and epileptic seizures. It is widely used among people with severe panic attacks and anxiety caused by depression treatment.

Other names for this medication:
Adnil, Almac, Clonapik, Clonasig, Clonatrac, Clonax, Cloneepam, Clonoasig, Clonopam, Clonotril, Clonzy, Clotweet, Cloze, Clozep, Clozipam, Cozil, Deptune, Dipwell, Easyfeel, Eminaz, Epizam, Escitrac, Estalonix, Ezinite, Jasoclam, Jbcloz, Lonipax, Lozep, Meloprax, Melzap, Nazee, Nozim, Prasilex, Prasilife, Repam, Rivotril, Sezolep, Somnolex, Somnotril, Ubitpam, Xenotril, Zeficar, Zepam, Zepamax, Zicam, Zolpidox, Zozep

Similar Products:
Anafranil, Actos, Rebetol, Imdur, Abilify, Bystolic, Priligy, Astelin, Desyrel, Combantrin, Dipax, Xitzen, Arcium, Buson, Osimet, Tupent,

Also known as: Clonazepam


Alrest, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Alrest has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Alrest. As a result, Alrest is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Alrest is mainly prescribed for the acute management of epilepsies. Alrest has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Alrest; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.


This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Alrest Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alrest if you have:

narrow-angle glaucoma; severe liver disease; or a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Alrest is safe for you, tell your doctor if you have ever had:

kidney or liver disease; breathing problems; depression, mood problems, or suicidal thoughts or behavior; or porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Some people have thoughts about suicide when taking seizure medication. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

If you use clonazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonazepam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Alrest is not approved to treat panic disorder in anyone younger than 18 years old.

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Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors. Varying degrees of noise were added to both types of Doppler recordings in order to simulate the problems encountered in the clinical vascular laboratory. Subtle or atypical injuries of the thoracic aorta and brachiocephalic vessels in blunt thoracic trauma. The examination separately assesses level of consciousness, orientation, and attention. We report two cases in which intrapartum sonographic assessment of a women with breech-presenting fetuses at 39 and 40 weeks of gestation depicted large lower uterine segment leiomyomas, which were considered an indication for cesarean. Estrogens exert a wide variety of actions on reproductive and non-reproductive functions.

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Outpatient management of superficial venous insufficiency at a naval medical facility. Our data indicate that an association between type 2 diabetes related SNPs and CAD exists. New means of surgical visualization are allowing more surgeries to be performed less invasively. Tooth transpositions--a review of the literature and treatment considerations. The OmpA protein was found to be translocated across the plasma membrane of both microorganisms. Washed platelets were aggregated at 20 or 37 degrees C with ADP (0-20 microM), arachidonic acid (0-200 microM), or the thromboxane mimetic U46619 (0-9 nM). The program had approximately 344,000 participants in 1975 and has grown to provide services to nearly 6 million participants. Radioprotective effect of S-(N-(3-aminopropyl)-2-aminoethyl)-thiophosphoric acid. These patients have unique characteristics and causes of injury. Anxiety disorders and symptoms are a common presenting problem in the elderly.

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It is instructive to take stock of this output to determine patterns of interest and where the cutting edge lies. A review of the literature and report of a case involving a homograft replacement of the aortic valve. The hypothetical mechanism of insulin buccal permeability which complies with published experimental data is proposed. No statistical differences were found for any of the variables observed. A rare complication of percutaneous transhepatic cholangiography. An NIH-3T3 transformant ability after treatment with sodium butyrate. Recombinant UAT protein that was expressed from the cloned cDNA in Escherichia coli and purified via immobilized metal affinity chromatography has been functionally reconstituted as a highly selective urate transporter/channel in planar lipid bilayers. Uni- and multivariate analysis was used to compare the recurrence interval and survival between different subgroups as defined by risk factors. Determination of serum cholesterol by near-infrared reflectance spectrometry. The effectiveness of these measures can vary depending on the natural attributes of the land in question (e.g., soil type, slope, and drainage class).

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The correlation coefficients (r) of the experimental and predicted Caco-2 apparent permeability for the training set and the test set were 0.88 and 0.85, respectively. In order to verify this notion, the number of experimental trials was quadrupled for 24 subjects of mixed sex in a replication of the initial paradigm. The occurrence of three different synergistically active bacterial species from one clinical specimen might be of clinical significance. Achievements and constraints to date and plans for the future are described. Many conditions of atypical development can lead to autism, including fragile X syndrome (FXS), which is presently the most common known single-gene cause of autism. Treating leaks following LSG based on the timing of presentation, presence of stricture, and malnutrition is safe and effective. Reassessment of a non-hemophilic reagent for factor VIII (AHF) determination. Birth preparedness and complication readiness (BP/CR) strategies are aimed at reducing delays in seeking, reaching, and receiving care. hislopii latex on the concentrations of total proteins and nitrogen products in Biomphalaria glabrata infected with Schistosoma mansoni.

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Poor growth and malnutrition are frequently reported in children with cerebral palsy in developed countries, but there is limited information from developing countries. Neutralization of TNF-alpha or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. A multidimensional parameter space, where each dimension is associated with one of the partition parameters, is introduced in order to describe the interaction between partitions and pulse sequence events (e.g., rf pulses and gradients). Detection of Saccharomyces cerevisiae chromosome size markers directly on Southern blots of pulsed-field gels with a single DNA hybridization probe. Little is known about alternative pain self-treatments used by HF patients with chronic pain.

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This interpretive phenomenological study identified three themes of schizophrenia and violence: Being Stigmatized, Foreclosing a Future of Possibilities, and Finding Meaning in Symptoms. Bacteriuria in children attending a primary health care clinic: a prospective study of catheter stream urine samples. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Anatomic bases of a vascularized allogenic knee joint transplantation: arterial blood supply of the human knee joint. In Drosophila, the Gal4/UAS method has been used to analyze in vivo such functional substitutions. To better understand the epidemiology of pertussis and optimize disease control, it is important to improve surveillance worldwide, irrespective of pertussis vaccine types and schedules used in each country. A focus for regulation is the initiation of the first replication forks, marking the transition from G1 to S phase. Calcium release from the mineral matrix of the mandibular bone due to hydrogen peroxide exposure. Finally, while referring to the literature, they discuss the way these factors might operate in the course of the disease.

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This study is an investigation of the impact of Type 1 diabetes on bone mineral density (BMD) with regard to bone composition. Population screening might provide a mechanism to enable early detection of dementia. The procedure smooths parameters and computes p-values locally to account for the complex structure of the genome and to more precisely estimate the differential expression of chromosomal regions. Characteristics of the repeat prosthesis of patients who have worn dentures for a long time. TLQoS exploits modular architecture wherein different modules perform integrated operations in providing multiple QoS service with lower temperature rise. It is concluded that lipids structurally and energetically maintain the neurosecretory material synthesis. Comparative clinical trial of tetracycline-oleandomycin combination and tetracycline in acute pharyngo-tonsillar infections. The effect of fluid from the cauda epididymidis, serum components and caffeine upon the survival of diluted epididymal hamster spermatozoa. However, each receptor splice variant differed in their ligand-stimulated efficacy for total inositol phosphate stimulation. The cells were able to incorporate 16 of 17 (14)C-labeled amino acids into cell protein, the exception being proline.

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Only three mutations, two present homozygously, are reported in the GTP cyclohydrolase I gene to cause the rare autosomal recessively inherited form of hyperphenylalaninemia. Microsatellite markers for powdery mildew resistance in pea (Pisum sativum L.). Both endogenous and exogenous GDF-9 was demonstrated to up-regulate focal adhesion associated proteins FAK and paxillin which contribute to promoted cell adhesion and motility. We report the development of a retroviral vector system in which two dominant oncogenes are expressed inducibly in human cells using the lac repressor/lac operator regulatable promoter system. Options for modulating intra-specific competition in colonial pinnipeds: the case of harbour seals (Phoca vitulina) in the Wadden Sea. Our findings demonstrate, for the first time, a role of CXCL12-CXCR4 signalling axis in conferring drug resistance to pancreatic cancer cells and suggest that it could serve as a novel therapeutic target for pancreatic cancer therapy, alone and in combination with the cytotoxic drug. A large-plot field experiment was carried out in Herefordshire, UK, during 2010-2011.

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The results of these tests are consistent with the model predictions. Twenty-four women with POF (study group) and 24 volunteers with normal ovarian cycles (control group). Collectively, our results suggest that TAP may modestly contribute to the MDR phenotype, in particular in MRP- overexpressing MDR cells. Spectroscopic evidence for preexisting T- and R-state insulin hexamer conformations. Nitrate therapy for ischemic heart disease and cardiac insufficiency. Mesenchymal stem cells for therapeutic applications in pulmonary medicine. The presence of commissural calcium is a strong predictor of outcome after percutaneous mitral balloon valvotomy. Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome.

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Our findings highlight the importance for clinicians to consider concomitant macro- and microstructural changes of the brain in patients with impaired kidney function. To explore the association between polycyclic aromatic hydrocarbons (PAHs) exposure and telomere length (TL), so as to investigate the effective biomarkers to evaluate the genetic damage in peripheral blood of workers exposed to PAHs. For crash and non-crash cases, geometric design/roadside and traffic characteristics were derived based on their milepost locations. The influence of peers and parents on the smoking behavior of schoolchildren. Given the increasing use of small molecule ErbB TKIs, identifying this mechanism is key to optimal cancer care. The second (high-dose) group received 6 mg/kg everolimus 1 day before, on the day of, and on the day after stenting, followed by 2 mg/kg/day for 4 days. A randomized comparison of vaginal misoprostol and dinoprostone for cervical priming in nulliparous women before operative hysteroscopy.

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Our whole-body computed tomography protocol (WBCT), used to image patients with polytrauma, consists of a noncontrast head computed tomography (CT) followed by a multidetector computed tomography (40- or 64- slice) that includes an intravenous, contrast-enhanced scan from the face through the pelvis. A less extensive surgery may be possible in patients with USC as it seems to provide the same information as a more extensive surgery. Purified anti-glycan proteins were used for an immunofluorescent analysis of Trypanosoma cruzi epimastigotes, and the anti-p185(HER2) used to determine the binding properties. To describe the disablement process in physically active persons with musculoskeletal injuries. The hydrophobic leucine residue lies within an amphipathic alpha-helix at the carboxyl terminus of TR beta and the position of the homologous residue in the crystal structure of TR alpha indicates that its side chain is solvent-exposed and might interact with other proteins. Value of posterior and right ventricular leads in comparison to the standard 12-lead electrocardiogram in evaluation of ST-segment elevation in suspected acute myocardial infarction. In contrast, rare mutations associated with substantially increased risk are likely to account for a smaller fraction of these differences.

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Tissue cores were initially obtained from the apical octants, followed by identical x and y coordinates of the basilar octants. This suggests that ectopic pregnancy is less suspected in these women. Lateral organ boundary formation is highly regulated by transcription factors and hormones such as auxins and brassinosteroids. To analyse the clinical outcome of women that had selective caesarean myomectomy in a community teaching hospital. It appears that most insects are rather sensitive and selective for the sex pheromone of their species.

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Physical examination including fundoscopy as well as imaging showed no abnormalities. To investigate the gastrointestinal motor mechanisms involved in the hyperglycaemia induced retardation of gastric emptying in patients with type I diabetes mellitus and autonomic neuropathy. Oleic acid increases absorption of the specific BCRP substrate mitoxantrone (MXR), and also BCRP gene expression in human intestinal Caco-2 cells, suggesting that oleic acid affect the BCRP function. Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism. Bacteriophages (phages) are vasotec iv cost ubiquitous viruses that control the growth and diversity of bacteria. These results are consistent with a reduction in neural synchrony in older adults to transient components of both speech and nonspeech sounds. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis.

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Neurological perspectives in insomnia and hyperarousal syndromes. Lectures are extremely efficient for delivering large amounts of information in a short period of time. Formation of pattern in regenerating tissue pieces of Hydra attenuata. Moreover the development of an anterior approach to access the tumor, further improved the technical challenges for a sound resection.The Anterior-manubrial sternal approach was described more than a decade ago and although this method facilitates better exposure of the extreme apex of the lung, brachial plexus and subclavian vessels, its popularity has not reached high levels. Moreover, a BI- duration-dependent exacerbation of various ulcerogenic parameters also was observed in these rats. Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes. In addition, deformation in the fat and in the muscle could be differentiated. The purpose of this study was to develop and validate a method for predicting expected accidents on main roads with minor junctions where traffic counts on the minor approaches are not available.

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Serum cholesterol level in normal people: association of serum cholesterol level with age and relative body weight. The second error arises from the spontaneous variability of blood pressure, such that single clinic readings may vary by as much as 20 mmHg. A rare case of adenocarcinoma arising in adenomyomatous hamartoma of the pyloric wall is presented and the literature reviewed. Imatinib mesylate is recommended as adjuvant therapy for GIST after surgical resection. The first disease-specific quality-of-life questionnaire in patients with drug hypersensitivity, Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q), was developed and validated recently.

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Classification of maxillary central incisors-implications for immediate implant in the esthetic zone. This study adds understanding of how community nurses might productively screen for mental health difficulties. Syntheses and applications of flavin analogs as active site probes for flavoproteins. Relative contribution of synaptic and non-synaptic influences to response decrements in a post-synaptic neurone. After this research was completed, PCV7 was switched to a PCV13 that also contained serotype 3 and serotype 19A. Careful is ventolin a steroid medication obstetric management and early postnatal intervention may lead to a favorable outcome. However, in recent years there has appeared literature making a case for the use of the date of birth as a starting point, and thus utilize age as the time-to-event.

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The length of this enhanced delay was similar in wild-type cells and in cell deficient in either homologous recombination or nucleotide excision repair. Curcumin and gemcitabine in patients with advanced pancreatic cancer. In order to control for multiple testing, permutation tests were used to generate corrected empirical p-values using the Max(T) procedure in PLINK. Immunosuppressive Therapies for the Maintenance Treatment of Proliferative Lupus Nephritis: A Systematic Review and Network Metaanalysis. The threshold of both filament-related and gill raker mechanoreceptors was relatively high. It may be integrated into future radio frequency ablation probes. Both array configurations demonstrated some movement after implantation. Defining and evaluating quality for ambulatory care educational programs. Trabecular pattern of the upper end of the femur in primary osteoarthrosis and in symptomatic osteoporosis. On the problem of organ transplantation with special reference to lung transplantation.

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Calcium and calmodulin are involved in blue light induction of the gsa gene for an early chlorophyll biosynthetic step in Chlamydomonas. Previous research has suggested a dose-response relationship between exposure to the 9/11 terrorist attacks and posttraumatic stress disorder (PTSD) and depression. Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen. Parameters affecting the use of the lac repressor system in eukaryotic cells and transgenic animals. Expanding endoprosthesis for pediatric musculoskeletal malignancy: current concepts and results. The electron-microscopic structure of the vasa recta of the kidney medulla of the rat under various fixation conditions. He received surgical treatment with frontal sinus curettage and obliteration with tibial bone graft and platelet-rich plasma (PRP). Purification and amino acid sequencing of naturally occurring N-formyl-methionyl oligopeptides from Escherichia coli. Different mechanisms and contributory factors for the development of AR are discussed.

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Conventional cytogenetics has proven to be useful for the detection of large aberrations, but its resolution limits the identification of submicroscopic alterations. Holt-Oram syndrome with associated postaxial and central polydactyly. Assessment of health-related quality of life after corneal transplantation. Therapy of these infections may be difficult as phenotypes famvir tab 500mg resistant to multiple antibiotics occur frequently. In addition, the productive performance of broiler chicks fed Opaque-2 corn or normal corn (Pioneer) for the first 28 days of age was evaluated. It allows almost anyone to access information available throughout the world. Furthermore, the P wave evoked by conditioning photic or acoustic stimuli depressed the P wave produced by cutaneous test stimuli.3. Both interventions decreased peak salicylic acid concentration, time-to-zero salicylic acid concentration, and AUC when compared with control (p less than 0.01). Clinically, both viral load and genotypes have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C and they are, under normal circumstances, performed as separate assays.

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Experimental autoimmune uveitis (EAU) is a T-cell-mediated autoimmune disease directed against retinal proteins and has been studied in several mammalian species including subhuman primates as a model for human what is the generic brand of lipitor posterior uveitis. To determine whether use of cardioselective beta-blockers, nonselective beta-blockers, ACE inhibitors, thiazide diuretics, calcium channel blockers, or other antihypertensive drugs alters the risk of developing serious hypoglycemia among older persons prescribed insulin or sulfonylureas. The consensus oligonucleotides should be valuable probes in the diagnosis and isolation of nucleic acids encoding proteins of the troponin C superfamily. A total of 2000 fecal specimens was investigated, 1000 from patients suffering from diarrhea and 1000 from healthy persons which served as controls. It has been established that the prognosis of the working ability largely depends on clinical (biological) and social factors (working education, familial status, living conditions, etc.). However, the molecular mechanisms regulating these intracellular transport events had not been studied until recently because of the lack of appropriate molecular assays and techniques. Radiofrequency catheter ablation for supraventricular tachycardias: experience at Peshawar. The expression of high-mobility group box protein-1 in temporomandibular joint osteoarthritis with disc perforation. Extending staining time to more than 8 h with chromosome suspensions isolated from cell lines subjected to sufficient metaphase arrest times gave the best result with the lowest percentage of debris generated, tighter chromosome peaks with overall lower coefficients of variation, and a 1- to 5-fold increase in the yield of isolated chromosomes.

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